NFL Week 1: Sunday slate highlighted by Cardinals upset over Chargers, Derrick Henry's history-making 3 TD effort

September 13, 2026

NFL Week 1 delivered an explosive slate of games, highlighted by Derrick Henry racking up 163 total yards and three touchdowns to lead a rout of the Colts, and Arizona pulling off a major upset against the Chargers. In another chaotic matchup, Minnesota lost Kyler Murray to a head injury during the first quarter of his Vikings debut, but backup Carson Wentz stepped in to guide a stunning comeback against Green Bay.

Minnesota tallied 29 consecutive points to finish a 39-22 win over the Packers, bolstered by three crucial defensive penalties from Green Bay and two Wentz touchdown strikes to Justin Jefferson, who also caught a go-ahead two-point conversion with 6:37 left on the clock.

Offenses set unprecedented marks elsewhere, as Chicago outdueled Carolina 59-37 in the highest-scoring Week 1 contest in league history and the twelfth-highest overall. Caleb Williams powered the Bears by throwing for two scores and rushing for a pair of touchdowns.

Additionally, Josh Allen guided the Bills to a tight victory against the Texans, securing his career-first road win in Houston.