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The Arizona Cardinals visit the Seattle Seahawks on Sunday, September 20, 2026, for a Week 2 divisional encounter. Arizona enters the contest following a 26-14 road triumph over Justin Herbert and the Los Angeles Chargers to open the head-coaching tenure of Mike LaFleur, who coordinates the squad alongside defensive planner Nick Rallis.
Despite that victory, sportsbooks have pegged the visiting Cardinals as ten-point underdogs.
Seattle, the reigning league champions, commenced their schedule with a win against the New England Patriots but lost quarterback Sam Darnold to a hip ailment during the contest. With Darnold sidelined, Drew Lock steps under center to guide the offense, while rookie Jadarian Price also features as the Seahawks deal with emerging injury worries on defense.

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