Packers vs. Vikings NFL betting: Odds, picks, predictions, start time for Week 1 showdown

Week 1 features an NFC North showdown as the Minnesota Vikings host the Green Bay Packers on CBS and Paramount+, following a 2025 campaign where Green Bay went 9-7-1 and Minnesota finished 9-8. Entering the contest, oddsmakers list the host Vikings as 1.5-point favorites with a money line of -122 to the Packers' +102, while the over/under stands at 46.5 total points.

Head coach Kevin O'Connell is opening a fresh chapter under center with Kyler Murray taking over following an unsuccessful stint with J.J. McCarthy.

Meanwhile, visiting quarterback Jordan Love must carry extra responsibility as Green Bay navigates significant roster absences on both sides of the ball. Running back Josh Jacobs is sidelined on the commissioner's exempt list due to legal troubles, elevating MarShawn Lloyd into the lead rushing role, while elite defender Micah Parsons remains out on the PUP list recovering from a December ACL tear.

The Packers do anticipate an offensive boost from tight end Tucker Kraft, who appears likely to suit up following his breakout 2025 campaign.

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