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NFL news, live updates: De'Von Achane knee injury 'not optimistic'; Justin Jefferson dealing with ankle injury

Following a busy third week of NFL action, several key players are dealing with worrisome physical setbacks. Miami Dolphins running back De'Von Achane exited early due to a knee issue, with coaching staff casting a grim outlook on his recovery.

Meanwhile, Minnesota Vikings star Justin Jefferson sustained an ankle problem, and San Francisco 49ers wide receiver Mike Evans was carted away after aggravating a rib injury. Elsewhere in the league, the New England Patriots stumbled to a one-and-two start as quarterback Drake Maye accumulated four interceptions against just one touchdown pass.

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NFL Week 4 injury report: Justin Jefferson out, Nico Collins in; Terry McLaurin suffers late-week injury