
After defeating the Rams during the league's historic initial regular-season fixture in Australia, the San Francisco 49ers have spent their second week of the campaign dealing with the physical fallout of an 8,000-mile return journey. Head coach Kyle Shanahan admitted to suffering several days of severe fatigue following the travel, while tight end George Kittle struggled to recalibrate his rest patterns and linebacker Fred Warner felt persistent sluggishness.
The 49ers now face a Miami Dolphins squad led by head coach Jeff Hafley that is seeking redemption after dropping its opening contest 27-13 against the Las Vegas Raiders. Miami opted to remain in California throughout the week to prepare for Sunday's matchup, navigating multiple roster absences as San Francisco designates two of its own primary contributors as questionable.

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