Dolphins vs 49ers predictions, prop bets, and odds in Week 2

Miami heads into Week 2 seeking its first win of 2026 after dropping its opener to the Las Vegas Raiders. The Dolphins travel to Levi's Stadium as massive 13.5-point underdogs against the 1-0 San Francisco 49ers, with kickoff slated for Sunday at 4:25 p.m. on FOX.

San Francisco comes into the contest backed by the defensive rush of Nick Bosa and an offense featuring Christian McCaffrey. Miami, which is managing an injury to Chop Robinson alongside record-setting contributions from Caleb Douglas, hopes to spark an offense led by running back De'Von Achane against the 49ers' defensive front overseen by Jeff Hafley.

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