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Broncos vs. 49ers odds: Opening lines for Week 4 matchup

Following a dramatic victory on Sunday Night Football, Sean Payton and the Denver Broncos hold a 2-1 record as they prepare to travel for a Week 4 matchup against the 3-0 San Francisco 49ers. FanDuel has established the visitors as 2.5-point underdogs, while the total points line is positioned at 46.5.

Led by Brock Purdy, the San Francisco offense has averaged over 30 points per contest through the early portion of the schedule. The upcoming contest is scheduled for Sunday, October 4, 2026, at Levi’s Stadium in Santa Clara.

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