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NFL Week 5 picks: Experts face off on Buccaneers at Cowboys, 49ers at Seahawks and more

The NFL’s Week 5 slate delivers high-stakes matchups as the league’s most dramatic season unfolds. With 18 games decided by game-winning drives in the final four minutes or overtime—tying for the second-most through Week 4—expect another round of clutch performances.

Tampa Bay’s Jalon Daniels, the undrafted rookie replacing Baker Mayfield, faces his first primetime test against the Dallas Cowboys, who average over 30 points per game. Meanwhile, the Philadelphia Eagles and Jacksonville Jaguars return to London, where the Jaguars, now AFC contenders, aim to silence doubts after the Eagles’ late-season collapse against the Rams.

The 49ers will host the reigning Super Bowl champion Seahawks in Seattle, while Josh Allen takes on Matthew Stafford on *Monday Night Football*—a clash of two of the league’s most explosive offenses.

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