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Roma faces a significant challenge at Old Trafford during their Champions League match against Manchester United, as starting goalkeeper Pierluigi Gollini has been ruled out due to acute back pain. Sporting director Tony D'Amico confirmed the setback but expressed total faith in backup keeper Devis Vasquez, who will take the starting position for this fixture.
Roma enters the game undefeated in domestic league play, while Manchester United seeks to break a nine-match winless streak under manager Michael Carrick.

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| # | Team | MP | W | D | L | GD | Pts |
|---|---|---|---|---|---|---|---|
| 1 | 9 | 8 | 0 | 1 | +9 | 24 | |
| 2 | 9 | 7 | 0 | 2 | +10 | 21 | |
| 3 | 9 | 6 | 1 | 2 | +17 | 19 | |
| 4 | 9 | 5 | 1 | 3 | +4 | 16 | |
| 5 | 9 | 4 | 3 | 2 | +2 | 15 | |
| 6 | 9 | 3 | 5 | 1 | +7 | 14 |