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Big Ten Football: Best Week 6 bets for Indiana - Nebraska, UCLA - Oregon, more
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College Football

Big Ten Football: Best Week 6 bets for Indiana - Nebraska, UCLA - Oregon, more

October 8, 2026

Week 6 of Big Ten football delivers a slate of intriguing matchups with strong betting angles. Indiana’s visit to Nebraska stands out as a potential upset opportunity, despite the Hoosiers’ 1-4 record against the spread.

The Cornhuskers, though unranked, have dominated their schedule with five blowout wins and a 4-1 record against the spread, making them a dark horse to pull off the upset against a defending national champion. Meanwhile, the UCLA-Oregon showdown offers a compelling total bet, with Oregon’s four straight over performances contrasting UCLA’s 3-1 record on the over.

In other action, Northwestern looks to extend its dominance in the Big Ten, while Iowa’s heavy betting percentage against Washington belies the shifting spread in their matchup.

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