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Oregon vs. UCLA prediction, pick, odds, spread: Bruins looking for signature win against shorthanded Ducks

The UCLA Bruins enter Oregon’s Autzen Stadium as a 4-0 team under first-year coach Bob Chesney, looking to build on a dominant 54-3 road win over Maryland that showcased their all-around offensive and defensive prowess. Facing a Ducks squad that lost starting quarterback Dante Moore to a concussion in their Week 4 victory over USC, Oregon will likely turn to Nebraska transfer Dylan Raiola, who stepped in for Moore and delivered a strong performance with 289 passing yards and two touchdowns in the Trojans game.

The Ducks, ranked No. 13 and coming off a 41-27 road win, are navigating a thin roster after an early-season upset loss at Oklahoma State, while UCLA—ranked No.

21—represents their first true test against a top-60 team in the CBS Sports rankings. With Big Ten implications on the line, this matchup could serve as a defining statement for both programs in their early-season trajectories.

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