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Arizona Cardinals-San Francisco 49ers 2026 week three discussion thread

The Arizona Cardinals face a challenging road matchup against the San Francisco 49ers during the third week of the 2026 NFL season. Kickoff is scheduled for Sunday, September 27, at 1:05 p.m. local time, with national television coverage provided by Fox and streaming available through FoxSports.

Heading into the contest, the Cardinals hold a one-and-one record while the Niners stand at two-and-zero, with FanDuel Sportsbook listing Arizona as 8.5-point underdogs. Roster adjustments include Arizona placing Will Johnson on injured reserve and signing Starling Thomas from the practice squad, while Nick Bosa is sidelined for the upcoming game.

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