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Arizona Cardinals offensive and defensive interior limited heading into Sunday

Arizona faces significant lineup uncertainty across the line of scrimmage ahead of a Week 2 matchup against the Seattle Seahawks. Coming off an opening-week triumph over the Los Angeles Chargers at SoFi Stadium, defensive lineman Roy Lopez sat out Thursday's practice session unexpectedly.

The 29-year-old had emerged as Arizona's top-graded performer according to Pro Football Focus with an overall mark of 90 in the opener. Both starting offensive guards also landed on the injury report, leaving six Cardinals listed as questionable and one competitor already ruled out for Sunday's NFC West clash.

Seattle carries injury concerns of its own heading into the divisional showdown, having ruled out two squad members while tagging another pair as questionable. Drew Lock is set to start under center for the Seahawks, bolstered by the return of receiver Tory Horton.

Arizona received a parallel boost as tight end Trey McBride resumed practice duties alongside three other teammates, offering a lift to a roster aiming to snap an extended losing stretch against their division rivals.