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NFL Week 2 opens with a Thursday Night Football matchup between the Detroit Lions and Buffalo Bills, marking the inaugural contest at Buffalo's brand-new Highmark Stadium. 5 total points.

Both squads arrive following shaky defensive performances in Week 1. Buffalo surrendered 381 total yards while generating 409 yards of their own during an away victory over Houston, fueled by Josh Allen alongside offensive targets James Cook and DJ Moore.

Detroit heads to Buffalo after surviving an overtime scare against New Orleans, who generated 469 yards behind quarterback Tyler Shough before failing on a decisive two-point try. Although Jared Goff finished with only 202 passing yards and Jameson Williams was limited to 45 yards on four receptions, Dan Campbell's group pulled through thanks to two touchdowns apiece from Jahmyr Gibbs—who produced 186 total yards—and Amon-Ra St.