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Use FanDuel promo code to score $350 in bonus bets for Lions vs. Bills on NFL Thursday Night Football

NFL Week 2 opens with a Thursday Night Football matchup between the Detroit Lions and Buffalo Bills, marking the inaugural contest at Buffalo's brand-new Highmark Stadium. The host Bills enter as 4.5-point favorites with an over/under set at 54.5 total points.

Both squads arrive following shaky defensive performances in Week 1. Buffalo surrendered 381 total yards while generating 409 yards of their own during an away victory over Houston, fueled by Josh Allen alongside offensive targets James Cook and DJ Moore.

Detroit heads to Buffalo after surviving an overtime scare against New Orleans, who generated 469 yards behind quarterback Tyler Shough before failing on a decisive two-point try. Although Jared Goff finished with only 202 passing yards and Jameson Williams was limited to 45 yards on four receptions, Dan Campbell's group pulled through thanks to two touchdowns apiece from Jahmyr Gibbs—who produced 186 total yards—and Amon-Ra St.

Brown. Computer simulations from SportsLine project the over 54.5 points hitting 57% of the time, while also giving Detroit a 42% chance to capture an outright road upset.

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