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Use FanDuel promo code to land $350 in bonus bets for Lions vs. Bills on NFL Thursday Night Football

Week 2 of the NFL calendar opens with a Thursday Night Football matchup between the Detroit Lions and Buffalo Bills, marking the inaugural contest at Buffalo's new Highmark Stadium. The host Bills enter as 5.5-point favorites with an over/under set at 54.5 total points, though defensive tackle Ed Oliver has been ruled out due to a hip issue.

Both squads are coming off high-yardage opening performances; Buffalo gained 409 yards while surrendering 381 in a victory against Houston, whereas Detroit conceded 469 yards—including 378 through the air to second-year quarterback Tyler Shough—before edging New Orleans in overtime when a two-point try failed.

Offensive firepower remains the central theme for the clash. Buffalo relies on quarterback Josh Allen alongside skill weapons James Cook and DJ Moore, while Dan Campbell's Detroit offense features Jared Goff distributing to Jahmyr Gibbs, Amon-Ra St.

Brown, and Jameson Williams. During their season opener, Gibbs racked up 186 total yards and two rushing scores, complementing a two-touchdown outing by St.

Brown, while Goff threw for 202 yards and Williams collected four receptions for 45 yards.

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