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Use FanDuel promo code to get $350 in bonus bets for Lions vs. Bills, NFL Thursday Night Football betting

The Buffalo Bills host the Detroit Lions for a Week 2 Thursday Night Football clash marking the opening contest at the new Highmark Stadium. Buffalo enters the home contest favored by 5.5 points, though the defense will be without tackle Ed Oliver due to a hip issue.

Dan Campbell's Detroit offense features weapons like Amon-Ra St. Brown, Jahmyr Gibbs, and Jameson Williams, while the Bills recently incorporated D.J.

Moore into quarterback Josh Allen's passing attack.

Following a 100-yard Buffalo debut against the Houston Texans, projections indicate Moore will register around 44.4 receiving yards, favoring the under on his 63.5-yard line. Meanwhile, simulations back the matchup's 54.5-point total to hit the over at a 56 percent clip, continuing an analytical run that has posted a 53-39 record on top-rated selections since 2024.

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