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The Buffalo Bills host the Detroit Lions for a Week 2 Thursday Night Football clash marking the opening contest at the new Highmark Stadium. 5 points, though the defense will be without tackle Ed Oliver due to a hip issue.

Dan Campbell's Detroit offense features weapons like Amon-Ra St. J.

Moore into quarterback Josh Allen's passing attack.

5-yard line. 5-point total to hit the over at a 56 percent clip, continuing an analytical run that has posted a 53-39 record on top-rated selections since 2024.