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                        Ohio State vs. Iowa prediction, pick, odds, spread: Buckeyes face another road test at Hawkeyes
Photo via CBS Sports
College Football

Ohio State vs. Iowa prediction, pick, odds, spread: Buckeyes face another road test at Hawkeyes

October 1, 2026

Fifth-ranked Ohio State is hitting the road to clash with fourteenth-ranked Iowa on Saturday afternoon in a high-stakes Big Ten matchup. The visiting Buckeyes are seeking to avoid a repeat of their previous trip to this venue in 2017 while navigating a challenging schedule featuring upcoming games against Indiana and Southern California.

Meanwhile, the home side enters with an unblemished four-game winning streak following a dramatic last-second triumph over Michigan in their previous outing, positioning the Hawkeyes for a potential surge in national ranking and postseason contention. Recent history heavily favors the visitors, who secured decisive victories in their last two meetings by margins of twenty-eight and forty-four points.

However, the hosts enter this contest displaying newfound offensive capabilities under quarterback Hank Brown, whose clutch final-drive touchdown pass against Michigan highlighted a renewed ability to execute in tight moments. Conversely, the visiting defense has experienced a noticeable dip in early-season production, currently sitting twenty-seventh nationally compared to their top-ranked finish the previous year.

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