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NFL Week 2 picks: Our experts face off on Lions at Bills Thursday night, Bengals vs. Texans and more

Week 2 of the NFL season features a high-profile Thursday night matchup as the Buffalo Bills host the Detroit Lions, entering as 4.5-point favorites with an over/under set at 54.5. Both franchises match the Philadelphia Eagles for the league's top record since 2023 at 37-15, and Buffalo is inaugurating the new Highmark Stadium, where entry tickets reached approximately $400 on Ticketmaster.

While Detroit boasts an NFL-best 14-3 record in primetime over the previous five seasons, Buffalo has claimed five consecutive victories over the Lions and won 10 of their last 12 home games in primetime. Furthermore, Lions quarterback Jared Goff is 0-3 against Buffalo despite averaging 351.7 passing yards per meeting, which includes an NFL-record defeat in which he posted 400 yards, five passing touchdowns, and zero interceptions.

Injuries along Detroit's offensive line could pose a challenge, with starting right tackle Blake Miller and starting left guard Christian Mahogany sidelined against a Buffalo defense that secured a Week 1 win by stripping Houston's C.J. Stroud.

Analysts anticipate offensive contributions from Buffalo's Josh Allen, James Cook, DJ Moore, and Dalton Kincaid, alongside Detroit's Goff, Amon-Ra St. Brown, and Jameson Williams, leading to a projected 36-30 Bills triumph.

Elsewhere across the Week 2 slate, Bo Nix and the Denver Broncos aim to rebound against the Jacksonville Jaguars, the Cincinnati Bengals' defense faces Stroud and the Texans, and the Kansas City Chiefs square off against the Indianapolis Colts on Sunday night.

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