Photo via CBS Sports

NFL Week 2 injury report: Lions down two starting offensive lineman vs. Bills, including Blake Miller

Health concerns are mounting across the league following an eventful kickoff week, highlighted by a battered offensive front for Detroit ahead of Thursday's matchup in Buffalo. J.

Reed carries a questionable tag because of a foot condition. J.

Sanders dealing with an illness and knee problem.

Several other high-profile setbacks have shifted rosters around the NFL entering the second slate of games. Concussions and soft tissue troubles cut short opening appearances for Vikings quarterback Kyler Murray and Sam Darnold respectively, sidelining Darnold for the upcoming week, while Chargers pass catcher Ladd McConkey was also injured in an upset defeat against Arizona.

J. Brown for an ankle problem, Eagles guard Landon Dickerson for a knee injury, and Rams edge defender Myles Garrett also due to his knee.