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NFL Week 1 odds, predictions, expert picks: Who has edge in Bills-Texans? Can Saints upset Lions?

The 2026 NFL campaign launches across four separate days, having already featured a Super Bowl rematch on Wednesday and international action in Australia on Thursday before heading into Sunday's slate and the Monday finale. Among the opening matchups, the Pittsburgh Steelers host the Atlanta Falcons on Sunday afternoon as three-point favorites with a 42.5-point total.

Atlanta enters having never won in Pittsburgh with an 0-7-1 record, facing a Steelers squad that shares the league's top mark as home favorites over the previous two years at 6-2 against the spread alongside Jacksonville. Veteran quarterback Aaron Rodgers brings strong history into the contest, boasting a 12-6 record, 32 passing scores, and 10 interceptions in Week 1 games throughout his career, which includes a four-touchdown opener last season.

Questions surround the visiting Falcons following their rapid offseason acquisition of Tua Tagovailoa, who has struggled during practices and exhibition play after joining the roster. While Atlanta features high-end skill contributors in Bijan Robinson, Drake London, and Kyle Pitts, injury has sidelined Michael Penix Jr., leaving Tagovailoa under center.

Analyst Jordan Dajani expects Pittsburgh to comfortably defeat Atlanta, even as the reigning AFC North champion Steelers face skepticism about securing another division title.

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