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NFL Week 1 odds, predictions, expert picks: Who has edge in Bills-Texans? Can Saints upset Lions?

The 2026 NFL campaign launches across four separate days, having already featured a Super Bowl rematch on Wednesday and international action in Australia on Thursday before heading into Sunday's slate and the Monday finale. 5-point total.

Atlanta enters having never won in Pittsburgh with an 0-7-1 record, facing a Steelers squad that shares the league's top mark as home favorites over the previous two years at 6-2 against the spread alongside Jacksonville. Veteran quarterback Aaron Rodgers brings strong history into the contest, boasting a 12-6 record, 32 passing scores, and 10 interceptions in Week 1 games throughout his career, which includes a four-touchdown opener last season.

Questions surround the visiting Falcons following their rapid offseason acquisition of Tua Tagovailoa, who has struggled during practices and exhibition play after joining the roster. , leaving Tagovailoa under center.