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Last minute best bets for NFL Week 1: Three underdogs are live, including C.J. Stroud and the Texans

The opening Sunday of the 2026 NFL regular season follows midweek matchups between Seattle and New England along with the Rams and 49ers, setting up a busy slate for bettors looking at DraftKings Sportsbook odds. In an AFC tilt, the Jacksonville Jaguars host the Cleveland Browns, who will start Deshaun Watson after he outperformed Shedeur Sanders during camp despite questionable summer form.

Todd Monken makes his debut leading a Cleveland team that has struggled away from home, logging an NFL-worst 4-13 record against the spread on the road across the previous two campaigns. Meanwhile, the Jaguars closed 2025 by beating the spread across eight consecutive weeks to finish at an NFL-best 12-5 ATS, and their offense features Trevor Lawrence in his second season running coordinator Liam Coen's system.

Backed by a pass rush powered by Josh Hines-Allen and Travon Walker, Jacksonville is projected to triumph 30-17 and cover an 8.5-point spread.

Later in the afternoon, an NFC East clash pits the Philadelphia Eagles against the visiting Washington Commanders, who enter the season following an injury-plagued 2025 campaign. Washington's offensive front faces a major setback after offensive tackle Laremy Tunsil suffered a torn triceps on August 8, presenting a tough challenge if Philadelphia pass rusher Jonathan Greenard can suit up despite a pectoral ailment.

The Commanders are also adjusting to several defensive additions, integrating newcomers Odafe Oweh, K'Lavon Chaisson, and Sonny Styles as they head on the road.

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