
The Los Angeles Rams head to the Mile High City carrying an eight-game winning streak against AFC opponents that began following a 23-15 defeat to the Miami Dolphins in 2024. During this run, Los Angeles secured victories over New England, Buffalo, the Jets, Houston, Tennessee, Indianapolis, Baltimore, and Jacksonville in London, bringing Sean McVay's overall record against the conference to 29-13.
Under the 17-game schedule format, the squad holds a 17-8 interconference mark, which features an undefeated 5-0 record through the 2025 season. Meanwhile, the Denver Broncos enter the matchup riding their own streak, seeking a tenth consecutive victory against NFC opponents.
That conference success surprised coach Sean Payton during media sessions, though Denver has historically struggled against Los Angeles regardless of who is on the sidelines. Previous McVay-era losses for the franchise came under Vance Joseph in 2018 and Nathaniel Hackett on Christmas day in 2022, leaving Denver without a head-to-head win since 2002.
Quarterback Bo Nix hopes to alter that trend, having only lost once in his career against the NFC during his professional debut against Seattle.

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