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Penn State Opens as Underdog Against USC

For the initial instance in the 2026 campaign, the Nittany Lions enter a matchup as betting underdogs, receiving 1.5 points at home against USC during their traditional White Out event. Following consecutive conference setbacks against Wisconsin and Northwestern that dropped their record to 3-2, oddsmakers display hesitation regarding the squad's prospects in University Park.

USC visits with a 5-1 record after edging Washington, setting up a clash at Beaver Stadium.

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