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Patriots vs. Bills opening odds: Pats seen as big underdogs against AFC East rivals

Entering Week 4 with a 1-2 record following a heavy defeat against Jacksonville, the defending divisional titleholders from New England head to upstate New York as significant underdogs against their undefeated conference rivals. FanDuel Sportsbook currently lists the hosts as 6.5-point favorites with a moneyline of -330, while the struggling visitors sit at +265 alongside a total set at 48.5 points.

The matchup is scheduled for an afternoon kickoff at 1 p.m. ET on Sunday, October 4.

Last season, the squad managed a narrow three-point upset victory on the road as nine-point underdogs, though the team will need to show major progress to repeat that performance given their current form.

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