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NFL predictions: Broncos vs. 49ers score predictions for Week 4

Ahead of a Week 4 matchup against the undefeated San Francisco 49ers, the Denver Broncos enter as 2.5-point underdogs holding a 2-1 record following consecutive comeback victories. Staff predictions for the contest at Levi's Stadium feature differing outcomes, with some analysts anticipating a narrow win for the visitors while others project a late rally falling short against the NFC opponents.

Kickoff is scheduled for Sunday, October 4, 2026, with betting odds pointing to an over/under line of 47.5 points.

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