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NFL betting, odds, lines: Betting trends to know for Week 4's biggest games

Three weeks into the 2026 NFL campaign, five undefeated squads remain, with Buffalo, Las Vegas, and Minnesota standing out as flawless both on the gridiron and against the point spread. Heading into Week 4, several notable matchups feature these unbeatens alongside struggling franchises.

The Patriots hit the road to face the Bills as 6.5-point underdogs following a 35-6 blowout loss to Jacksonville, while Buffalo aims to maintain momentum after overcoming a slow start against the Chargers. Elsewhere, the Jaguars and Bengals each hold a 2-1 record as they prepare for their respective fixtures following differing Week 3 outcomes.

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