
The Detroit Lions head on the road to play the Carolina Panthers at Bank of America Stadium on Sunday, October 4, 2026, with kickoff scheduled for 8:20 p.m. ET.
Detroit comes in with a 2-1 record, averaging 31 points per contest while allowing 31.7, and currently sits as a 3.5-point favorite with a total set at 51.5. Meanwhile, the Panthers hold a 1-2 record, posting 29.7 points offensively and giving up 27.7 defensively, with a moneyline of plus-162 compared to Detroit's minus-194.
Quarterback play and rushing dynamics highlight the matchup as Carolina leads the league in passing yards per game behind a strong aerial attack, while Detroit counters with heavy production from the backfield following a dominant multi-touchdown performance.

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