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Commanders vs. Colts odds: Opening lines for Week 4 matchup
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NFL

Commanders vs. Colts odds: Opening lines for Week 4 matchup

September 28, 2026

Washington enters Week 4 with a 1-2 record following an upset victory over Seattle, steered by new team captain Marcus Mariota after Jayden Daniels suffered a left elbow injury. The squad is preparing to travel to London for an international contest against Indianapolis, who similarly secured their first win of the season by defeating Houston.

FanDuel lists the Commanders as 3.5-point underdogs for the matchup abroad, with an over-under point total set at 47.5. The Indianapolis moneyline opens at -174 while Washington sits at +146, setting the stage for a compelling cross-Atlantic battle.

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