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College football Week 5 picks for Top 25 games, including SEC, Big Ten showdowns

Week 5 of the college football season features several key matchups, highlighted by a Big Ten contest between fourteenth-ranked Iowa and sixth-ranked Ohio State after Iowa's recent victory against Michigan. In the SEC, seventh-ranked Alabama visits sixteenth-ranked Mississippi State in an undefeated clash, while eighth-ranked Florida travels to twenty-fifth-ranked Missouri.

Additional notable games include fourth-ranked Miami playing at Clemson and third-ranked Notre Dame facing North Carolina.

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