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Bills vs. Rams Week 5 opening odds reveal a first for Buffalo in 2026

The Buffalo Bills are preparing to face the Los Angeles Rams in a Monday Night Football matchup for Week 5, marking the first time this season that Buffalo opens as underdogs. FanDuel lists the Bills as 2.5-point underdogs with an over/under set at 53.5.

Both teams enter this contest holding 2-2 records after experiencing mixed results in their opening four games, alongside various injury concerns across their rosters.

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