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Week 4 NFL odds, picks, predictions: Computer model backs Giants and Seahawks

As the NFL approaches the fifth week of the 2026 season, the fourth week slate features sixteen matchups, including the league's inaugural game in London between the Indianapolis Colts and the Washington Commanders, where Indianapolis is favored by three and a half points. Additional games on Sunday include the New England Patriots facing the Buffalo Bills, who are favored by six and a half points, and the Kansas City Chiefs meeting the Las Vegas Raiders.

On Monday night, the New Orleans Saints take on the Atlanta Falcons as two and a half point favorites, marking the twentieth anniversary of the Domecoming event.

Heavy favorites also appear elsewhere on the schedule, with the Baltimore Ravens favored by eleven and a half points against the Tennessee Titans, while the Minnesota Vikings hold a ten and a half point advantage over the Miami Dolphins. Ahead of these matchups, a simulation computer model has run every game ten thousand times and enters the fourth week with a forty-three loss record alongside fifty-four wins on top-rated selections since the 2024 season.

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