Photo via CBS Sports

Week 4 NFL odds, betting lines, spreads, totals, for every game, including Texans-Cowboys, Raiders-Chiefs

Week four of the National Football League season brings a packed slate of matchups, featuring clashes between the Dallas Cowboys and Houston Texans, the Kansas City Chiefs and Las Vegas Raiders, and the Detroit Lions and Carolina Panthers. In early betting lines for Sunday, October 4, 2026, the winless Texans are favored by 2.5 points over the Cowboys, while other notable spreads include the Philadelphia Eagles giving three points against the Los Angeles Rams, the Raiders getting 4.5 points against the Chiefs, and the Panthers receiving 3.5 points versus the Lions.

Additionally, the Rams will miss Aaron Donald due to a back injury for their meeting with Philadelphia.

Further matchups on the Sunday schedule include the Indianapolis Colts hosting the Washington Commanders with a 3.5-point spread and a 47-point total, the Buffalo Bills favored by 6.5 points against the New England Patriots with a 48.5 total, and the Baltimore Ravens heavily favored by 11.5 points over the Tennessee Titans with a total of 43.5. Finally, the Chicago Bears are listed as three-point favorites against the New York Jets in a matchup carrying a 43-point total.

Up nextNFL· 26m ago

Commanders roster moves: Washington elevates two from practice squad vs. Colts