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Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

As the NFL approaches the third week of the 2026 season, an advanced predictive algorithm has completed ten thousand simulations for every upcoming matchup. Among the highlighted games, the Buffalo Municipal team is established as a seven-point favorite over the Chargers, while Seattle travels to face Washington as a seven-point-five-point favorite.

Washington will turn to Marcus Mariota under center due to an elbow injury sidelining Jayden Daniels, whereas Sam Darnold enters the Seattle lineup without any injury concerns. Additionally, a historic international fixture takes place in South America as the Dallas franchise plays the Baltimore squad in Rio de Janeiro, with Dallas entering the contest as three-point-five-point underdogs.

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