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How to bet on 2026 Week 5 college football: Betting guide, trends, odds, previews, promos, apps, schedule

The upcoming fifth week of the college football calendar presents numerous wagering opportunities alongside nearly $3,000 in promotional sign-up bonuses across various mobile applications. Ohio State enters its road matchup against Iowa as a 13.5-point favorite with an over-and-under line set at 45.5 points.

Another major matchup features Miami laying 17.5 points on the road against Clemson. Additional games on the slate include Missouri versus Florida, Colorado matching up with Texas Tech, and USC playing Washington.

Meanwhile, North Carolina, led by Bill Belichick, is scheduled to face off against Notre Dame in a prominent non-conference fixture.

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