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How to bet on 2026 NFL Week 4: Betting odds, trends, tips, schedule, game previews, sportsbook promos, offers

Week four of the professional football calendar brings an international matchup between Washington and Indianapolis as the opening contest of a three-game series across the Atlantic. Indianapolis enters as a 3.5-point favorite with an over/under set at 47 points.

Later in the day, Detroit takes a 3.5-point road advantage into its nighttime clash against Carolina with a total line of 50.5 points. Several franchises including Houston, Los Angeles, and Tampa Bay navigate early struggles after starting the campaign with three consecutive defeats.

Major wagering platforms are offering sign-up promotions and bonus bets across multiple states where online sports gambling is authorized.

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