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What To Watch For: Syracuse Orange

Syracuse’s defense faces a major test against Louisville’s high-powered offense, which ranks as the most explosive in college football. The Orange must contain explosive plays from receivers stretching the field, a challenge Louisville struggled with against Florida State last week.

Syracuse’s third-string quarterback, Malachi Nelson, has shown inconsistency under center, and the Cardinals will aim to disrupt his rhythm by pressuring him in the pocket. With Syracuse committing the most penalties in the nation and missing 54% of field goals this season, Louisville has multiple avenues to exploit if they can capitalize on turnovers or special teams opportunities.

Defensively, Louisville’s aggressive scheme—including extra defenders in the box and blitzing linebackers—proved effective against FSU’s run game. The Cardinals will need to replicate that intensity to limit Syracuse’s ground attack, while cornerback Tayon Holloway could play a pivotal role in shutting down the Orange’s vertical threats.

Syracuse’s inability to sustain leads and their struggles in red-zone situations add further pressure, as Louisville looks to seize control early in a must-win game for both teams.

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