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Week 4 NFL odds, picks, predictions: Computer model backs Giants and Seahawks

As the NFL approaches the fifth week of action, the upcoming slate marks the final week featuring a full set of sixteen games before bye weeks begin. League play heads across the Atlantic for its first international contest in London, where the Indianapolis Colts enter as four-and-a-half-point favorites against the Washington Commanders without Jayden Daniels.

Additional matchups feature the New England Patriots laying seven points against the Buffalo Bills, the Kansas City Chiefs facing the Las Vegas Raiders, and the New Orleans Saints hosting the Atlanta Falcons for the twentieth anniversary of the Domecoming game. Heavy favorites include the Baltimore Ravens against the Tennessee Titans following a game in Rio de Janeiro, and the Minnesota Vikings favored over the Miami Dolphins despite an injury to Justin Jefferson.

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