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Enzo Maresca has overhauled his Manchester City starting eleven for this pivotal Champions League clash against RB Leipzig, making four adjustments following a weekend loss to Brighton. With the club aiming for a third victory in four group stage matches to maintain a top-eight trajectory, the manager has introduced Marc Guehi, Nico O’Reilly, Rayan Cherki, and Phil Foden into the lineup.
Antoine Semenyo remains sidelined for the hosts due to a long-term knee injury that will keep him out until December. The starting side features Gianluigi Donnarumma in goal, supported by a mix of defensive and attacking options including Erling Haaland, Matheus Nunes, and Enzo Fernandez.
Ruben Dias, Josko Gvardiol, Ayyoub Bouaddi, and Jeremy Doku have been moved to the bench for this fixture.

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| # | Team | MP | W | D | L | GD | Pts |
|---|---|---|---|---|---|---|---|
| 1 | 9 | 8 | 0 | 1 | +9 | 24 | |
| 2 | 9 | 7 | 0 | 2 | +10 | 21 | |
| 3 | 9 | 6 | 1 | 2 | +17 | 19 | |
| 4 | 9 | 5 | 1 | 3 | +4 | 16 | |
| 5 | 9 | 4 | 3 | 2 | +2 | 15 | |
| 6 | 9 | 3 | 5 | 1 | +7 | 14 |