Photo via Yahoo Sports

Oklahoma State vs. Houston prediction, odds, pick for Big 12 clash in Week 7

Oklahoma State and Houston square off in a high-stakes Big 12 showdown this weekend, with both teams vying for conference dominance. The Cowboys (4-1) enter the matchup after a strong start to conference play, winning their last two games, including a 42-28 victory over UCF to move to 2-0 in Big 12 action.

Their season began with a loss to Tulsa but quickly rebounded with a narrow win over sixth-ranked Oregon, followed by a decisive 41-24 victory over West Virginia that snapped an 18-game conference losing streak. Meanwhile, Houston (5-1) looks to avoid its second conference loss after a close 28-26 defeat to Texas Tech earlier this season.

The Cougars have since won three straight, including victories over Georgia Southern, UCF, and Kansas State, and are seeking their first home win since 2006 in a rivalry that has seen Houston hold a slight edge in their 23 prior meetings, including a 39-17 win over Oklahoma State last year.

The matchup carries added intrigue with betting trends favoring Oklahoma State, who are 4-1 against the spread this season and 2-0 as underdogs. The Cowboys have also seen the over hit in three of their last five games, adding another layer of strategy for bettors.

Injuries could play a role, with key players like Oklahoma State’s Landon Dean and Houston’s Jaden Yates among those dealing with setbacks. With both teams pushing for Big 12 supremacy, this clash promises to be a pivotal moment in the conference race.

Up nextCollege Football· 24m ago

College Football Playoff nearing future 24-team format