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NFL Week 5 picks, odds: Jaguars bludgeon Eagles in London, Colts get exposed

As the NFL season transitions into its fifth week following a brutal stretch of against-the-spread results, a notable scheduling disadvantage has caught the attention of analysts. The Indianapolis Colts face a demanding travel sequence, coming off an overseas contest in London and immediately hitting the road to take on a well-rested Pittsburgh Steelers squad playing on extended rest.

Meanwhile, struggling quarterback performances and lingering injuries continue to plague the Colts as they prepare for Sunday's matchup at home for Pittsburgh.

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