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NFL predictions: Will Rams-Cardinals be Aaron Donald’s “big” game?

The Los Angeles Rams enter their Week 6 showdown against the Arizona Cardinals seeking to rebound from a gut-wrenching overtime loss to the Buffalo Bills. With quarterback Jacoby Brissett facing a Rams defense looking to capitalize on turnovers, predictions suggest the secondary will force two interceptions—one of which could result in a pick-six by cornerback Trent McDuffie.

Meanwhile, the Rams’ offense may turn to rookie kicker Blake Grupe for a field goal attempt, likely within 40 yards, as head coach Sean McVay leans on aggressive fourth-down strategies. The spotlight will also shine on defensive tackle Aaron Donald, who could finally record three sacks after a Week 5 game where a defensive holding penalty cost him a sack against Josh Allen.

Donald’s increased snap count and dominance in multi-sack games over the past decade make him a key factor in this NFC West clash. On the ground, tight end Tyler Higbee is expected to continue his standout 2026 season with another 60-plus yard performance, potentially reaching 100 yards in a critical matchup for Rams’ divisional hopes.

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