Photo via CBS Sports

Jaguars vs. Bengals odds, picks, prediction, spread, line: NFL Week 4 start time, preview, best bets

Week 4 of the 2026 NFL season brings a clash at Paycor Stadium where the Cincinnati Bengals host the Jacksonville Jaguars in a rematch of their meeting from two years prior. Cincinnati enters the contest with quarterback Joe Burrow available after previous health concerns, as the squad looks to secure another victory over their AFC rivals.

Kickoff is scheduled for 1 p.m. ET with the Bengals opening as 2.5-point favorites and an over/under set at 51.5 points.

Jacksonville arrives following a convincing 35-6 triumph over New England, a contest where quarterback Trevor Lawrence tossed three touchdowns and the defensive unit forced three turnovers against Drake Maye. Meanwhile, analytical projection models suggest a closely contested battle between these postseason contenders based on thousands of prior game simulations.

Up nextNFL· 34m ago

Bills Mafia confident Buffalo will defeat New England Patriots in Week 4