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Patriots vs. Bills odds, picks, prediction, spread: NFL Week 4 start time, betting preview, best bets

Quarterback Drake Maye leads the New England Patriots into an important AFC East divisional contest on the road against the Buffalo Bills this Sunday. Kickoff is scheduled for 1 p.m. ET, with the Buffalo squad positioned as 6.5-point favorites and the betting total established at 48.5 points.

The Buffalo attack features quarterback Josh Allen alongside teammate James Cook III, with Dalton Kincaid, DJ Moore, and Keon Coleman also contributing through the air. The SportsLine Projection Model indicates extensive simulation data supports the ongoing betting analysis for this matchup.

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