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Detroit Lions road underdogs at Buffalo Bills in Week 2

Following high-scoring opening-week triumphs for both squads, FanDuel has set betting lines that designate Detroit as the away underdog against Buffalo for their upcoming Week 2 showdown. The matchup comes on the heels of a previous encounter between the two franchises on December 15, 2024, when the Bills edged the Lions 48-42 at Ford Field.

Each franchise enters the tilt after narrowly prevailing in high-stakes opening contests to launch the 2026 season. Buffalo secured a victory over the Houston Texans behind a record-setting late drive spearheaded by Josh Allen, marking Joe Brady's initial victory as head coach.

Meanwhile, Detroit opened its campaign by dispatching the New Orleans Saints, though defensive secondary play surfaced as a notable area of concern moving forward.