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Big 12 football Week 6 picks, predictions for every conference matchup

Week 6 of Big 12 football brings a mix of high-stakes matchups and program challenges, as three teams remain in contention for a late-season title push. Colorado’s season takes a breather with its lone bye week of 2026, arriving after a three-game losing streak that has intensified scrutiny over the program’s offensive struggles and leadership.

Meanwhile, the conference’s schedule is light, with just six games total—five of them on Saturday—highlighted by a showdown between No. 8 BYU and Iowa State on Friday night.

The Cougars, led by a dominant defense featuring six players with interceptions or sacks, aim to maintain their undefeated record despite key injuries, including the absence of running back L.J. Martin.

Elsewhere, Houston at Kansas State and Arizona at West Virginia promise competitive battles, while Oklahoma State’s explosive offense, anchored by quarterback Drew Mestemaker, looks to extend its momentum against UCF. Baylor, Cincinnati, Texas Tech, and TCU sit out this week, leaving the remaining teams to shape the early December landscape.

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