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49ers vs. Broncos: How to watch, game time, and betting odds

The San Francisco 49ers prepare to wrap up a three-game homestand by welcoming the Denver Broncos for a high-stakes matchup. While the San Francisco offense boasts league-leading numbers and recently outlasted the Arizona Cardinals, Brock Purdy could be playing through a rib injury to top target Mike Evans, prompting the promotion of Brandin Cooks and Jordan Watkins.

Meanwhile, Denver arrives following a stunning 30-26 comeback win against the Los Angeles Rams, overcoming a sixteen-point halftime deficit behind the defensive heroics of former 49ers safety Talanoa Hufanga and quarterback Bo Nix. Both rosters grapple with significant injury concerns as San Francisco misses key defenders like Nick Bosa and Mykel Williams, while the Broncos rule out Dondrea Tillman.

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