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2026 Week 6 college football odds, betting lines, spreads, start times: Predictions, picks, best bets

College football’s Week 6 features 55 FBS matchups, offering a wealth of betting opportunities across major conferences. The Red River Rivalry reignites with Texas favored by 7.5 points over Oklahoma, while Oregon holds an 11.5-point edge at home against UCLA, with the over/under set at 59.5 points.

The SEC delivers a showdown between Alabama and Georgia, where Alabama is a 1.5-point favorite in what’s billed as the conference’s biggest game of the week. High-profile Friday and Saturday contests include Iowa State at No.

8 BYU (-10.5, 46.5) and Fresno State vs. Boise State (-6.5, 48.5), both offering sharp lines for sharp bettors.

Promotions from DraftKings, FanDuel, and BetMGM provide lucrative sign-up bonuses, including up to $1,500 in bonus bets at BetMGM, making Week 6 a prime time for wagering on underdog upsets and high-scoring affairs.

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