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College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 5

Week 5 features a slate of marquee college football matchups highlighted by fifth-ranked Ohio State visiting fourteenth-ranked Iowa following the Hawkeyes' dramatic victory over Michigan. In the SEC, seventh-ranked Alabama travels to face sixteenth-ranked Mississippi State in Starkville, while eighth-ranked Florida matches up against twenty-fifth-ranked Missouri.

Elsewhere, Auburn visits seventeenth-ranked Tennessee amid off-field controversy surrounding an arrest, eleventh-ranked BYU plays TCU, Bill Belichick's North Carolina hosts third-ranked Notre Dame, and South Carolina takes on twenty-fourth-ranked Kentucky.

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