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Week 6 NFL odds, picks, predictions: Computer model backs Patriots and Cardinals

Week 6 of the NFL presents a slate of high-stakes matchups, with SportsLine’s advanced computer model offering sharp predictions ahead of the action. Divisional games dominate the Sunday lineup, including the Ravens facing the Browns with a +4.5 underdog spread, while the Patriots enter as +7.5 underdogs against the Jets.

The Cardinals, meanwhile, are favored by 12.5 points over the Rams, and the Chiefs—coming off a bye—are slight underdogs at +8.5 against the Chargers, though their recent form following byes raises questions. The Panthers, also off a bye, square off against the Eagles, who are just one point ahead despite a late loss in London.

The Bills, meanwhile, are heavy road favorites at +4.5 over the Raiders, who suffered their first spread loss of the season to the Patriots last week. Four games feature over/under totals of 50 or higher, setting the stage for high-scoring affairs across the league.

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