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Week 5 NFL odds, spreads, totals, betting lines, for all 16 games, including Buccaneers-Cowboys, Bears-Packers

The NFL’s Week 5 slate kicks off with Thursday Night Football’s marquee clash between the Dallas Cowboys and Tampa Bay Buccaneers, where Dallas enters as the 9.5-point favorite. The Cowboys’ home advantage and point spread reflect their status as one of the league’s top contenders, though Tampa Bay’s offense remains a threat to disrupt underdog odds of +380 on the moneyline.

Meanwhile, the Bears host the Packers in a potential underdog story, with Chicago favored by just 3 points—a tight margin that underscores the Packers’ recent struggles and the Bears’ resurgence. The 49ers and Seahawks also draw attention as San Francisco holds a 3-point edge, while the Bills and Rams square off in a closely contested matchup, with Buffalo favored by 2.5 points.

The Jaguars-Eagles game in London adds an international twist, with Philadelphia favored by 6.5 points, and the Texans and Titans present another high-scoring showdown, with Houston favored by 7 points. Over/under totals range from 39.5 to 47.5, reflecting the league’s high-scoring trends and the unpredictability of Week 5 matchups.

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